| Commonly Used Antidepressants: Suitability in Lactation | |||||
|---|---|---|---|---|---|
| Drug Name | Drug Class | Half-Life | Adult Dose | Relative Infant Dose | Lactation Risk Category |
| AMITRIPTYLINE | Tricyclic | 31-46 h | 10-300 mg daily (varies). | 1.08%-2.8% | L2 - Limited Data-Probably Compatible |
| BREXANOLONE | Other | 9 h | Administered IV over 60 hours. | 1%-2% | L2 - Limited Data-Probably Compatible |
| BUPROPION | NDRI | 8-24 h | 150 mg twice a day SR. | 0.11%-1.99% | L3 - Limited Data-Presumed Compatible |
| CITALOPRAM | SSRI | 36 h | 20-40 mg daily. | 3.56%-5.37% | L2 - Limited Data-Probably Compatible |
| DESVENLAFAXINE | SNRI | 11 h | 50-100 mg/day. | 5.9%-9.3% | L3 - Limited Data-Presumed Compatible |
| DEXTROMETHORPHAN- BUPROPION | NMDA Antagonist |
22 h | 45mg/105mg twice daily. | L4 - No Data-Possibly Hazardous | |
| DULOXETINE | SNRI | 12 h | 40-60 mg daily | 0.12%-1.12% | L3 - Limited Data-Presumed Compatible |
| ESCITALOPRAM | SSRI | 27-32 h | 10-20 mg daily. | 5.2% - 7.9% | L2 - Limited Data-Probably Compatible |
| FLUOXETINE | SSRI | 2-3 days | 20-60 mg daily. | 1.6% - 14.6% | L2 - Limited Data-Probably Compatible |
| FLUVOXAMINE | SSRI | 15.6 h | 50-300 mg daily | 0.3% - 1.4% | L2 - Limited Data-Probably Compatible |
| GEPIRONE | Other | 5 h | 15-60 mg daily | L3 - No Data-Presumed Compatible | |
| LEVOMILNACIPRAN | SNRI | 12 h | 40-120 mg daily | 2.57% | L3 - No Data-Presumed Compatible |
| MIRTAZAPINE | NASA | 20-40 h | 15-45 mg daily. | 1.6% - 6.3% | L3 - Limited Data-Presumed Compatible |
| NEFAZODONE | SARI | 1-4 h | 150-300 mg daily | 1.20% | L4 - Limited Data-Possibly Hazardous |
| NORTRIPTYLINE | Tricyclic | 16-90 h | 25 mg three times daily | 1.7%-3.36% | L2 - Limited Data-Probably Compatible |
| PAROXETINE | SSRI | 21 h | 20-50 mg daily. | 1.2%-2.8% | L2 - Limited Data-Probably Compatible |
| SERTRALINE | SSRI | 26 h | 50-200 mg daily. | 0.4%-2.2% | L2 - Limited Data-Probably Compatible |
| TRAZODONE | SARI | 4-9 h | 150-400 mg daily | 1.06% - 2.8% | L2 - Limited Data-Probably Compatible |
| VENLAFAXINE | SNRI | 5 h | 75-225 mg/day ER | 6.85% - 10.89% | L2 - Limited Data-Probably Compatible |
| VORTIOXETINE | SSRI | 66 h | 20 mg per day. | 1.22% - 1.85% | L3 - Limited Data-Presumed Compatible |
| ZURANOLONE | Other | 19.7-24.6 h | 50 mg at bedtime | 0.36% | L2 - Limited Data-Probably Compatible |
