Commonly Used Benzodiazepines—Suitability in Lactation

Commonly Used Benzodiazepines: Suitability in Lactation
Drug Name Half-Life Adult Dose Relative Infant Dose Lactation Risk Category
ALPRAZOLAM 12-15 h 0.5-1 mg three times a day 8.50% L3 - Limited Data-Presumed Compatible
CLOBAZAM 36-42 h 20-30 mg daily 4.38%-5.33% L3 - Limited Data-Presumed Compatible
CLONAZEPAM 18-50 h 0.5-1 mg three times a day 2.80% L3 - Limited Data-Presumed Compatible
DIAZEPAM 43 h 2-10 mg 2-4 times per day as needed 0.88%-7.14% L3 - Limited Data-Presumed Compatible
LORAZEPAM 12 h 1 mg two-three times a day as needed 2.6% - 2.9% L3 - Limited Data-Presumed Compatible
MIDAZOLAM 3 h 1-2.5 mg IV (varies by indication and route of adminis- tration) 0.63% L2 - Limited Data-Probably Compatible
OXAZEPAM 8 h 10-30 mg 3-4 times a day 0.28%-1% L2 - Limited Data-Probably Compatible
TEMAZEPAM 9.5-12.4 h 7.5-30 mg daily L3 - Limited Data-Presumed Compatible
TRIAZOLAM 1.5-5.5 h 0.125-0.25 mg daily L3 - No Data-Presumed Compatible