Commonly Used Migraine Medications: Suitability in Lactation

  • Appendices
  • Commonly Used Migraine Medications: Suitability in Lactation

Commonly Used Migraine Medications: Suitability in Lactation
Drug Name Drug Class Half-Life Adult Dose Relative In- fant Dose Lactation Risk Category Use
ACETAMINOPHEN Analgesic 2 h 1 gm orally every 6 hours if needed 6.41%-8.82% L1 - Extensive Data-Compatible Abortive
ALMOTRIPTAN Triptan 3-4 h 6.25-12.5 mg orally, may repeat in 2 hours if needed Unknown L3 - Limited Data-Presumed Compatible Abortive
AMITRIPTYLINE TCA 31-46 h 10-300 mg orally daily 1.08%-2.8% L2 - Limited Data-Probably Compatible Preventative
ATOGEPANT CGRP 11 h 10-60 mg daily Unknown L3 - Limited Data-Presumed Compatible Preventative
BUPIVACAINE Local anesthetics 2.7 h 2 mL (0.5% occipital block) 0.14% - L2 - Limited Data-Probably Compatible Abortive
2.92%
BUTALBITAL Barbituate 35 h 50-100 mg every 4 hours Unknown L3 - No Data-Presumed Compatible Abortive
CANDESARTAN ARB 9 h 16 mg orally daily Unknown L3 - No Data-Presumed Compatible Preventative
COENZYME Q10 Other 34 h 400 mg orally daily Unknown L3 - No Data-Presumed Compatible Preventative
DIHYDROERGOTA- MINE Ergotamine 28 h 2 mg intranasally if needed Unknown L4 - Limited Data-Possibly Hazardous Abortive
DIVALPROEX SO- DIUM Antiepileptic 14 h 125-250 mg orally daily 0.99%-5.6% L4 - Limited Data-Possibly Hazardous Preventative
ELETRIPTAN Triptan 4 h 20-40 mg initially, may repeat in 2 hours if needed 0.02-0.8% L3 - Limited Data-Presumed Compatible Abortive
EPTINEZUMAB CGRP monoclo- nal antibodies 27 days 100 mg IV ever 3 months Unknown L3 - No Data-Presumed Compatible Preventative
ERENUMAB CGRP monoclo- nal antibodies 28 days 70-140 mg subcutane- ously monthly Unknown L3 - No Data-Presumed Compatible Preventative
ERGOTAMINE Other 21 h 2 mg every 30 minutes
(max 3 doses).		 Unknown L4 - Limited Data-Possibly Hazardous Abortive
FREMANEZUMAB CGRP monoclo- nal antibodies 31 days 225 mg subcutaneously once a month Unknown L3 - No Data-Presumed Compatible Preventative
FROVATRIPTAN Triptan 26 h 2.5 mg orally, may repeat in 2 hours if needed Unknown L3 - No Data-Presumed Compatible Abortive/
Preventative*
GALCANEZUMAB CGRP monoclo- nal antibodies 27 days 120-240 mg subcutane- ously once a month Unknown L3 - No Data-Presumed Compatible Preventative
IBUPROFEN NSAID 1.8-2.5 h 600-1200 mg orally every 12 h if needed 0.12%-0.66% L1 - Extensive Data-Compatible Abortive
KETOROLAC NSAID 2.5 h 30-60 mg IM or IV if needed 0.14% - 0.2% L2 - Limited Data-Probably Compatible Abortive
LASMIDITAN Ditan 5.7 h 50-200 mg orally at bedtime Unknown L4 - No Data-Possibly Hazardous Abortive
LIDOCAINE Local anesthetics 1.5-2 h 2 mL (2% occipital block) 0.5% - 3.1% L2 - Limited Data-Probably Compatible Abortive
MAGNESIUM SUL- FATE Mineral < 3 h 400 mg orally at bed- time 0.20% L1 - Limited Data-Compatible Abortive/ Preventative
MEMANTINE NMDA Receptor antagonist 60-80 h 5 -10 mg orally daily Unknown L3 - No Data-Presumed Compatible Preventative
NARATRIPTAN Triptan 6-7 h 1-2.5 mg orally, may repeat in 4 hours if needed 4.99% L3 - Limited Data-Presumed Compatible Abortive/
Preventative*
ONABOTULINUM- TOXIN A Other Variable 155 units intramuscu- larly every 3 months Unknown L3 - No Data-Presumed Compatible Preventative
PROPRANOLOL Other 3-5 h 10-240 mg orally daily 0.3%-0.5% L2 - Limited Data-Probably Compatible Preventative
RIBOFLAVIN Vitamin B2 14 h 400 mg orally daily Unknown L1 - No Data-Compatible Preventative
RIMEGEPANT CGRP 11 h 75 mg as needed per 24 hours or every other day 0.52% L2 - Limited Data-Probably Compatible Abortive/
Preventative
RIZATRIPTAN Triptan 2-3 h 5-10 mg orally/film, may repeat in 2 hours if needed 0.27% -1.78% L3 - No Data-Presumed Compatible Abortive
SUMATRIPTAN Triptan 2-3 h 25-100 mg orally, may repeat in 2 hours if needed 0.53% -3.51% L3 - Limited Data-Presumed Compatible Abortive
TIZANIDINE Aplha2 Adrener- gic Agonist 13-22 h 2-4 mg orally every 6 hours as needed Unknown L4 - No Data-Possibly Hazardous Abortive
TOPIRAMATE Antiepileptic 21 h 25-200 mg orally daily 24.68% -55.65% L3 - Limited Data-Presumed Compatible Preventative
UBROGEPANT CGRP 5-7 h 20-100 mg. Second dose at 2 hours if necessary Unknown L3 - No Data-Presumed Compatible Abortive
VERAPAMIL Other 3-7 h 120 mg orally daily 0.20% L2 - Limited Data-Probably Compatible Preventative
ZAVEGEPANT CGRP 6.55 h 10 mg intranasally if needed Unknown L3 - No Data-Presumed Compatible Abortive
ZOLMITRIPTAN Triptan 3 h 2.5 mg orally or nasally, may repeat in 2 hours if needed 0.63% -4.25% L3 - No Data-Presumed Compatible Abortive
*for menstral migraine